Asian Journal of Cardiology Research https://journalajcr.com/index.php/AJCR <p style="text-align: justify;"><strong>Asian Journal of Cardiology Research</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJCR/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Cardiology research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> en-US contact@journalajcr.com (Asian Journal of Cardiology Research) contact@journalajcr.com (Asian Journal of Cardiology Research) Fri, 17 Jan 2020 09:35:25 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Role of Neutrophil to Lymphocyte Ratio (NLR) In Conjunction with Coronary Artery Involvement as a Biomarker for the Magnitude of Current of Injury, Type of Intervention and Clinical Outcomes in STEMI https://journalajcr.com/index.php/AJCR/article/view/30100 <p><strong>Background:</strong> The potential prognostic biomarker—neutrophil to lymphocyte ratio (NLR) can be used to predict the severity of STEMI. We conducted an observational study using this parameter together with the extent of coronary artery involvement from coronary angiogram and magnitude of ST-elevation on ECG to determine the prognosis and the length of hospital stay. The effect of early reperfusion with thrombolysis was also observed.</p> <p><strong>Methods and Results:</strong> 30 subjects (age 56.43 ± 13.98), with ST-elevation on ECG at admission, treated with streptokinase and undergoing angiogram were taken for the study. Repeated ECGs and complete blood picture on admission day, day 3, day of discharge and on the follow-up day were obtained. Out of 30 subjects, 15 received thrombolysis out of which 12 (80%) survived compared to the other 15 subjects who presented late, out of which 10 (66.6%) survived. Mean ST-elevation on the day of admission, on day 3, day of discharge and on follow up was found to be 0.39 ± 0.12, 0.18 ± 0.12, 0.05 ± 0.07, 0.00 ± 0.00 respectively. NLR values on admission day were 7.89 ± 4.98, day 3 (6.24 ± 5.05), day of discharge (4.34 ± 2.74) and on follow up (1.71 ± 1.40) indicating association of higher NLR values with magnitude of current of injury. NLR values as high as 18.5 were observed in expired subjects. The length of hospital stay was found to be 6.43 ± 5.03 days.</p> <p><strong>Conclusion:</strong> There was a linear decrement in ST-segment resolution with a decrease in NLR and can be attributed to the natural course of disease and type of intervention provided. Nevertheless, the univariate correlation between ECG and NLR on various days of treatment was not significant.</p> Mohammed Abdul Hannan Hazari, Kailas Laxman Rao, Bachi Tazneem, Sara Sana Ayesha Khanum, Huma Quadri, Syeda Kehkashan Jabeen ##submission.copyrightStatement## https://journalajcr.com/index.php/AJCR/article/view/30100 Fri, 17 Jan 2020 00:00:00 +0000 Early Detection of Heart Disease Using Gated Recurrent Neural Network https://journalajcr.com/index.php/AJCR/article/view/30101 <p>Cardiovascular disease (CVD) is an important factor in life since it may cause the death of human by effecting the heart and blood vessels of the body. Early detection of this disease is necessary for securing patients life. For this purpose, an automated tool is proposed in this paper for detecting patients with CVD and assisting health care systems also. A stacked-GRU based Recurrent Neural Network model, abbreviated as, stk-G, is proposed in this paper that considers interfering factors from past health records while detecting patients with cardiac problems. This proposed model is compared with two benchmark classifiers known as Support Vector Machine (SVM) and K-Nearest Neighbour (K-NN). The comparative analysis concludes that the proposed model offers enhanced efficiency for heart disease prediction. A promising result is given by the proposed method with an accuracy of 84.37%, F1-Score of 0.84 and MSE of 0.16.</p> Shawni Dutta, Samir Kumar Bandyopadhyay ##submission.copyrightStatement## https://journalajcr.com/index.php/AJCR/article/view/30101 Sun, 07 Jun 2020 00:00:00 +0000 Risk of Thromboembolism in Nonvalvular Atrial Fibrillation https://journalajcr.com/index.php/AJCR/article/view/30102 <p><strong>Background:</strong> Atrial fibrillation is associated with atrial thrombus formation and peripheral embolization, which leads to ischemic stroke or systemic thromboembolism. The CHADS2, CHA2DS2-VASc scores are tool for estimating risk of stroke in nonvalvular atrial fibrillation (NVAF) patients. Data on scores variables, Body mass index (BMI) and chronic kidney disease (CKD) with reduced glomerular filtration rate on their implication in identify thromboembolic events (TE) in Saudi population with NVAF are quite limited.</p> <p><strong>Methods:</strong> The study consisted of 541 patients with AF seen in our institution from 2008 to 2013 were identified in database, 175 were NVAF. Thromboembolic end points were defined as ischemic stroke and systemic embolism. During follow - up period of 730 days. CHADS2, CHA2DS2-VASc scores components, BMI also CKD and association with TEs end points identified by Cox regression analysis.</p> <p><strong>Results:</strong> Of 175 patients with NVAF, 26 (14.9%) patients were identified to have TEs. Majority of them had stroke. Age (&gt;or =75 years) and Peripheral vascular disease were significant factors for TEs. Thromboembolic risk in patients had previous stroke or TIA was 38.5% (P value =.000). Events rate of thromboembolism increased when CHADS2/ CHA2DS2-VASc score increased. No statistically significant associations were observed with BMI and TEs. Study has shown Despite only 35% of study population is suffering from CKD however level of estimated glomerular filtration rate were significant factor for TEs in patients with nonvalvular atrial fibrillation.</p> <p><strong>Conclusion:</strong> Study demonstrated CHADS2, CHA2DS2-VASc, CKD are predictor of TEs and should be included in risk stratification schemes among NVAF Saudi patient. While obesity was not predicator for TEs. So, keeping this association in consideration during thromboembolism risk assessment is recommended. Further study is needed to search for modifiable risk factors that are associated with increased risk thromboembolism in NVAF patient In addition to the conventional CHADS2/ CHA2DS2-VASc scheme.</p> AlHarbi, Hassan M., Abdulazizi I. Alroshodi, Ghazi T. AlMutairi, Abdullah A. Alfhaid, Mashari Alzahrani, Khaled A. Alqarni, Naif Saad Alghasab, Alzead, Ahmed A., Mashary A. Attamimi, Fahad Alshehri ##submission.copyrightStatement## https://journalajcr.com/index.php/AJCR/article/view/30102 Thu, 09 Jul 2020 00:00:00 +0000 Levels of Adiponectin and GDF-15 in Adult Male Cigarette Smokers in Nnewi Metropolis https://journalajcr.com/index.php/AJCR/article/view/30103 <p><strong>Background:</strong> Adiponectin is the most abundant adipokine in human plasma that plays a crucial role in the pathophysiology of metabolic syndrome, atherosclerosis and insulin resistance. On the other hand, growth differentiation factor-15 (GDF15) is a stress responsive cytokine linked to obesity-associated diseases such as cardiovascular disease, inflammation, and cancer.</p> <p><strong>Aim:</strong> This was a cross sectional study designed to evaluate the serum levels of adiponectin and GDF-15 in adult adult male cigarette smokers.</p> <p><strong>Materials and Methods:</strong> A total of 80 subjects comprising 40 smokers and 40 non-smokers within the age range of 18 to 60 years were selected for this study. Serum levels of adiponectin and GDF-15 were determined using enzyme linked immunosorbent assay (ELISA) method.</p> <p><strong>Results:</strong> The mean value of adiponectin was significantly lower (p&lt;0.05) among smokers than non-smokers while the mean value of GDF-15 was of non-significant difference when compared with smokers and non-smokers (p&gt;0.05). Furthermore, there was a significant negative correlation between the levels of adiponectin when compared with the frequency (r=-0.364) and duration of smoking (r=-0.529) (p&lt;0.05) respectively. On the other hand, the mean level of GDF-15 showed a significant negative association (r=-0.445 and p=0.040) between the duration of smoking and a non-significant negative correlation between smoking frequency (r=-0.265 and p=0.099).</p> <p><strong>Conclusion:</strong> The significant reduction in the mean levels of adiponectin amongst smokers and the significant negative correlation between serum level of GDF-15 and the duration of smoking among smokers suggests a high level of cardio-metabolic risk in cigarette smokers. Further cardiovascular related study of adiponectin and Growth Differentiation Factor-15 is recommended to buttress the cardio-metabolic potentials of adiponectin and GDF-15.</p> P. O. Manafa, O. Okoye, O. Ekuma- Okereke, R. S. Ebugosi, G. O. Chukwuma, N. C. Ibeh, R. C. Chukwuanukwu, V. I. Manafa, K. E. Nwene, C. E. Onah, O. S. Ogbuowelu ##submission.copyrightStatement## https://journalajcr.com/index.php/AJCR/article/view/30103 Sat, 22 Aug 2020 00:00:00 +0000