Asian Journal of Cardiology Research

Background & Aims: ST-segment elevation myocardial infarction (STEMI) is uncommon in young women and may present with features that initially suggest an alternative diagnosis. To report a deferred, optical coherence tomography-guided revascularization strategy for a high-thrombus-burden left main-left anterior descending artery bifurcation lesion in a young woman with ST-segment elevation myocardial infarction and a concomitant left ventricular thrombus.

Presentation of Case: This case describes a 25-year-old active smoker with no known cardiovascular history presented with prolonged chest pain and diffuse ST-segment elevation with biphasic T waves, initially raising suspicion of acute myocarditis. Echocardiography demonstrated apical akinesia with preserved ejection fraction and a mobile apical thrombus. Coronary angiography with optical coherence tomography (OCT) revealed a severe thrombotic stenosis of the ostial-proximal left anterior descending artery (LAD) extending into the left main (LM) coronary artery, with a distal LAD embolic occlusion. A staged strategy was adopted: therapeutic anticoagulation for one week followed by OCT-guided LM-LAD bifurcation angioplasty, with complete technical and angiographic success (TIMI 3 flow). Aetiological work-up revealed marked hyperhomocysteinaemia; despite a family history suggestive of autoimmune disease, the patient's own thrombophilia and antiphospholipid work-up did not confirm a defined heritable or acquired prothrombotic disorder; only isolated low-titre antinuclear antibodies were detected.

Discussion: This case illustrates the practical value of OCT for guiding a deferred, staged revascularization strategy in a high-thrombus-burden LM-LAD bifurcation lesion, and for informing individualised antithrombotic decision-making in the presence of a concomitant left ventricular thrombus.

Conclusion: A deferred, OCT-guided strategy allowed safe revascularization of a high-thrombus-burden LM-LAD bifurcation lesion in this young woman, with complete angiographic success. Even with a suggestive family history, an aetiological work-up in a young patient with an unprovoked atherothrombotic event may not confirm a prothrombotic disorder; this does not diminish the value of performing the work-up.