Complete Congenital Atrioventricular Block in a Nigerian Neonate of a Previously Undiagnosed and Asymptomatic Mother with Systemic Lupus Erythematosus: A Case Report
Asian Journal of Cardiology Research,
Congenital atrioventricular block is a rare disorder with an incidence of 1 in 22,000 cases. Its diagnosis is devastating to parents anywhere in the world, and even more so in a resource limited country like in Nigeria. We report the case of Baby E. who was first suspected to be having a complex congenital heart disease in utero at 26 weeks of gestation. He was delivered to an apparently healthy 25-year primigravida who was later found to have serological features of systemic lupus erythematosus (SLE). We also highlight the challenges and proffer recommendations for management of congenital atrioventricular block in Nigeria.
- atrioventricular block
- systemic lupus erythematosus
How to Cite
Askanase AD, Friedman DM, Copel J, Dische MR, Dubin A, Starc TJ, et al. Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies. Lupus. 2002;11(3):145–51.
Kertesz NJ, Fenrich AL, Friedman RA. Congenital complete atrioventricular block. Texas Hear Inst J. 1997;24(4):301–7.
Friedman D, Duncanson L, Glickstein J, Buyon J. A review of congenital heart block. Images Paediatr Cardiol. 2003 Jul;5(3):36–48.
Bordachar P, Zachary W, Ploux S, Labrousse L, Haissaguerre M, Thambo JB. Pathophysiology, clinical course, and management of congenital complete atrioventricular block. Hear Rhythm. 2013;10(5):760–6.
Friedman DM, Rupel A, Glickstein J, Buyon JP. Congenital heart block in neonatal lupus: The pediatric cardiologist’s perspective. Indian J Pediatr. 2002;69(6):517–22.
Nkoke C, Wawo EY, Mfeukeu LK, Makamte L, Edie SD, Balana FE. Complete congenital heart block in a neonate with a complex congenital heart defect in Africa. Cardiovasc Diagn Ther. 2016;6:S78–82.
Antia AU. Congenital heart disease in Nigeria Clinical and necropsy study of 260 cases. Arch of Disease Child. 1974;36.
Capone C, Buyon JP, Friedman DM, Frishman WH. Cardiac manifestations of neonatal lupus: A review of autoantibody- associated congenital heart block and its impact in an adult opulation. Cardiology in Review. 2012;20:72–6.
Alexander E, Buyon JP, Provost TT, Guarnieri T. Anti-Ro/SS-A antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome, an experimental model. In vitro electrophysiologic and immunocytochemical studies. Arthritis Rheum. 1992;35(2):176–89.
Friedman DM, Llanos C, Izmirly PM, Brock B, Byron J, Copel J, et al. Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: Results of a multicenter, prospective, open-label clinical trial. Arthritis Rheum. 2010;62(4):1138–46.
Moak JP, Barron KS, Hougen TJ, Wiles HB, Balaji S, Sreeram N, et al. Congenital heart block: Development of late-onset cardiomyopathy, a previously underappreciated sequela. J Am Coll Cardiol. 2001;37(1):238–42.
Adelowo OO, Olaosebikan BH, Animashaun BA, Akintayo RO. Juvenile systemic lupus erythematosus in Nigeria. Lupus. SAGE Publications Ltd. 2017;26:329–33.
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