Heart and Brain Crisis: The Unseen Drama of Acute Cardio-Cerebral Infarction Type 1

Akhmad Isna Nurudinulloh *

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

Budi Satrijo

Supervisor of Invasive Diagnostic and Non-Surgical Intervention Division, Department of Cardiology and Vascular Medicine, Dr. Saiful Anwar Regional General Hospital, Malang, Indonesia.

*Author to whom correspondence should be addressed.


Abstract

Background: Cardio-cerebral infarction (CCI) type 1 is a rare condition where acute myocardial infarction (AMI) and acute ischemic stroke (AIS) occur at the same time. The optimal method for diagnosing and treating AMI in patients with AIS remains uncertain. This publication aims to delineate the obstacles associated with the treatment of CCI.

Case Illustration: A 69-year-old man with the risk factors hypertension, active smoker, and history of cerebral infarction presented with atypical angina at rest and left hemiparesis. The patient's electrocardiography revealed sinus rhythm and ST elevation with pathological Q wave in the inferoposterior and RV region. The cardiac enzyme level was increased while hs-troponin I was 23.091 ng/L and CKMB was 387 U/L. The Brain CT Scan demonstrated acute infract at lentiformis nucleus dextra and corona radiata dextra. Patient was decided to get loading dual anti-platelet and anticoagulant and performed Primary PCI after bleeding risk assessment. Coronary angiography showed CAD three-vessel disease and left main coronary artery disease with acute total occlusion at mid-RCA with thrombus appearance. The patient underwent coronary stenting in the proximal-mid RCA using DES Cre8 3.0 x 46 mm. Cineangiography evaluation showed TIMI Flow 3 and no residual stenosis. Patient also was joined care with Neurology department to treat AIS simultaneously. Patient improved and was discharged on the 7th day of hospitalization.

Conclusion: Effectively managing CCI poses a significant challenge for professionals. PCI strategy for AMI as the first strategy due to high mortality remains the preferred choice despite the risk of hemorrhagic transformation in AIS.

Keywords: Cardio-cerebral infarction, acute myocardial infarction, acute ischemic stroke


How to Cite

Akhmad Isna Nurudinulloh, and Budi Satrijo. 2024. “Heart and Brain Crisis: The Unseen Drama of Acute Cardio-Cerebral Infarction Type 1”. Asian Journal of Cardiology Research 7 (1):1-6. https://journalajcr.com/index.php/AJCR/article/view/193.


References

Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics—2020 update a report from the American Heart Association. Circulation. 2020; 141(9):E139–596.

Yeo LLL, Andersson T, Yee KW, Tan BYQ, Paliwal P, Gopinathan A, et al. Synchronous cardiocerebral infarction in the era of endovascular therapy: Which to treat first? J Thromb Thrombolysis. 2017 Jul 1;44(1):104–11.

Podolecki TS, Lenarczyk RK, Kowalczyk JP, Mazurek MH, Świa̧tkowski AM, Chodór PK, et al. The risk of stroke in patients with acute myocardial infarction treated invasively. Coron Artery Dis. 2012 Jan; 23(1):9–15.

Omar HR, Fathy A, Rashad R, Helal E. Concomitant acute right ventricular infarction and ischemic cerebrovascular stroke; Possible explanations. Int Arch Med. 2010;3(1).

Zinkstok SM, Roos YB. Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: A randomised controlled trial. The Lancet. 2012;380(9843):731–7.

Patel MR, Meine TJ, Lindblad L, Griffin J, Granger CB, Becker RC, et al. Cardiac tamponade in the fibrinolytic era: Analysis of >100 000 patients with ST-segment elevation myocardial infarction. Am Heart J. 2006 Feb;151(2):316–22.

Alqahtani F, Aljohani S, Tarabishy A, Busu T, Adcock A, Alkhouli M. Incidence and outcomes of myocardial infarction in patients admitted with acute ischemic stroke. Stroke. 2017 Nov 1;48(11):2931–8.

Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. Lippincott Williams and Wilkins; 2019;50:E344–418.

Dutta M, Hanna E, Das P, Steinhubl SR. Incidence and prevention of ischemic stroke following myocardial infarction: Review of current literature. Cerebrovascular Diseases. 2006;22: 331–9.

Kijpaisalratana N, Chutinet A, Suwanwela NC. Hyperacute simultaneous cardiocerebral infarction: Rescuing the brain or the heart first? Front Neurol. 2017 Dec 7;8(DEC).

Ay H, Koroshetz WJ, Benner T, Vangel MG, Melinosky C, Arsava EM, et al. Neuroanatomic correlates of stroke-related myocardial injury [Internet]; 2006. Available:www.neurology.org

Nolte CH, Von Rennenberg R, Litmeier S, Scheitz JF, Leistner DM, Blankenberg S, et al. Prediction of acute coronary syndrome in acute ischemic stroke (PRAISE)-protocol of a prospective, multicenter trial with central reading and predefined endpoints. BMC Neurol. 2020 Aug 27; 20(1).

Scheitz JF, Nolte CH, Doehner W, Hachinski V, Endres M. Stroke–heart syndrome: Clinical presentation and underlying mechanisms. The Lancet Neurology. Lancet Publishing Group. 2018; 17:1109–20.

Ibekwe E, Kamdar HA, Strohm T. Cardio-cerebral infarction in left MCA strokes: A case series and literature review. Neurological Sciences. 2022 Apr 1;43(4): 2413–22.

Van E, Oh L, Artin M, Ohn STJ, Utton S, Huan HC, et al. Ventricular dysfunction and the risk of stroke after myocardial infarction abstract. 1997;336.

Kijpaisalratana N, Chutinet A, Suwanwela NC. Hyperacute simultaneous cardiocerebral infarction: Rescuing the brain or the heart first? Front Neurol. 2017 Dec 7;8(DEC).

Gungoren F, Besli F, Tanriverdi Z, Kocaturk O. Optimal treatment modality for coexisting acute myocardial infarction and ischemic stroke. American Journal of Emergency Medicine. 2019 Apr 1;37(4): 795.e1-795.e4.

Gungoren F, Besli F, Tanriverdi Z, Kocaturk O. Optimal treatment modality for coexisting acute myocardial infarction and ischemic stroke. American Journal of Emergency Medicine. 2019 Apr 1;37(4): 795.e1-795.e4.

Lee K, Park W, Seo KD, Kim H. Which one to do first?: A case report of simultaneous acute ischemic stroke and myocardial infarction. Journal of Neurocritical Care. 2021 Dec 1;14(2):109–12.

Ciccone A, Abraha I, Santilli I. Glycoprotein IIb-IIIa inhibitors for acute ischemic stroke. Stroke. 2007;38:1113–4.

Lee M, Saver JL, Hong KS, Rao NM, Wu YL, Ovbiagele B. Risk-benefit profile of long-term dual-versus single-antiplatelet therapy among patients with ischemic stroke A systematic review and meta-analysis [Internet]; 2013.

Available:www.annals.org

Akinseye OA, Shahreyar M, Heckle MR, Khouzam RN. Simultaneous acute cardio-cerebral infarction: Is there a consensus for management? Ann Transl Med. 2018 Jan;6(1):7–7.

Mannino M, Asciutto S, Terruso V, Gammino M, Cellura MG, Monaco S. Myocardial infarction following intravenous thrombolysis for acute ischemic stroke: Case report and literature review. Journal of Stroke and Cerebrovascular Diseases. 2017 Jun 1;26(6):105–7.

Sandercock PAG, Counsell C, Kane EJ. Anticoagulants for acute ischaemic stroke. Cochrane Database of Systematic Reviews. John Wiley and Sons Ltd. 2015; 2015.