The Impact of Ayurveda-based Ischemia Reversal Program (IRP) and Poly-herbal Medication on Reduction of Resting Myocardial Ischemia’

Rohit Sane *

Madhavbaug Cardiac Hospitals and Clinics, India.

Rahul Mandole

Department of Research and Development, Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India.

Gurudatta Amin

Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India.

Pravin Ghadigaonkar

Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India.

Prafull Yashwantrao

Madhavbaug Hospital Khopoli, Thane, Maharashtra, India.

Rahul Jadhav

Madhavbaug Hospital Khopoli, Thane, Maharashtra, India.

*Author to whom correspondence should be addressed.


Abstract

Aims: To evaluate the effect of an Ayurvedic-based ischemic reversal program (IRP) and a calorie-controlled diet to treat myocardial ischemia in patients with known chronic heart disease (CHD).

Study Design: Single arm, prospective study.

Place and Duration of Study: Madhavbaug Clinics throughout India, between June 2020 and August 2020.

Methodology: Patients with myocardial ischemia were screened using 2D speckle tracking global longitudinal strain (GLS) echocardiography. The selected patients underwent a baseline investigation along with a 6-minute walk test and assessment of the left ventricular ejection fraction, end diastolic volume (EDV), stroke volume and left ventricular mass. The study group were administered 14 IRP Panchakarma (twice a day) for 7 days and followed a calorie-controlled diet for 30 days. Post 30 days of treatment, the GLS score, 6-minute walk test, left ventricular ejection fraction, EDV, stroke volume and left ventricular mass were measured and compared with the baseline results.

Results: On screening 67 patients, 50 patients with a GLS score of ≥16 were selected for the study. The study population consisted of 43 males aged 59.37 ± 10.45 years and 7 females aged 63.14 ± 6.40 years. Post IRP treatment and calorie-controlled diet, the GLS score reduced from -10.77% to -12.13%. 6-minute walk test result improved thus indicating the improvement in the functional capacity of the patients. The left ventricular ejection fraction, EDV and stroke volume increased thus improving the cardiac output. Reduction in the left ventricular mass was observed which indicates a reduction of the risk of cardiovascular events.

Conclusion: The IRP and calorie-controlled diet helped to reduce the myocardial ischemic condition in the study population and the effect of the treatment was evaluated using speckle tracking global longitudinal strain echocardiography.

Keywords: Myocardial ischemia, global longitudinal strain, 6-minute walk test, ischemic reversal program, calorie controlled diet, cardiac output


How to Cite

Sane , Rohit, Rahul Mandole, Gurudatta Amin, Pravin Ghadigaonkar, Prafull Yashwantrao, and Rahul Jadhav. 2023. “The Impact of Ayurveda-Based Ischemia Reversal Program (IRP) and Poly-Herbal Medication on Reduction of Resting Myocardial Ischemia’”. Asian Journal of Cardiology Research 6 (1):190-96. https://journalajcr.com/index.php/AJCR/article/view/157.

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References

Rezende PC, Ribas FF, Serrano CV Jr, Hueb W. Clinical significance of chronic myocardial ischemia in coronary artery disease patients. J Thorac Dis. 2019; 11(3):1005-1015.

Remme WJ. Overview of the relationship between ischemia and congestive heart failure. Clin Cardiol. 2000;23(7 Suppl 4): IV4-8.

Bonfim MR, Oliveira AS, do Amaral SL, Monteiro HL. Treatment of dyslipidemia with statins and physical exercises: recent findings of skeletal muscle responses. Arq Bras Cardiol. 2015;104(4):324-31.

Pollentier B, Irons SL, Benedetto CM, Dibenedetto AM, Loton D, Seyler RD, Tych M, Newton RA. Examination of the six minute walk test to determine functional capacity in people with chronic heart failure: A systematic review. Cardiopulm Phys Ther J. 2010;21(1):13-21

Beatty AL, Schiller NB, Whooley MA. Six-minute walk test as a prognostic tool in stable coronary heart disease: Data from the heart and soul study. Arch Intern Med. 2012;172(14):1096-102.

Zielińska D, Bellwon J, Rynkiewicz A, Elkady MA. Prognostic value of the six-minute walk test in heart failure patients undergoing cardiac surgery: A literature review. Rehabil Res Pract. 2013; 2013:965494.

Karlsen S, Dahlslett T, Grenne B, Sjøli B, Smiseth O, Edvardsen T, Brunvand H. Global longitudinal strain is a more reproducible measure of left ventricular function than ejection fraction regardless of echocardiographic training. Cardiovasc Ultrasound. 2019;17(1):18

Park JJ, Park JB, Park JH, Cho GY. Global longitudinal strain to predict mortality in patients with acute heart failure. J Am Coll Cardiol. 2018;71(18):1947-1957.

Bouzas-Mosquera A, Broullón FJ, Álvarez-García N, Peteiro J, Mosquera VX, Castro-Beiras A. Association of left ventricular mass with all-cause mortality, myocardial infarction and stroke. PLoS One. 2012; 7(9):e45570.

Sane R, Wadekar A, Shinde K, Furia H, Upadhyay P, Mandole R. Understanding the role of ayurveda based ischemia reversal program and low carbohydrate diet in reduction of risk of heart disease. Asian J Cardiol Res. 2019;2(1):1–8.

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28(1): 1-39.e14.

Yingchoncharoen T, Agarwal S, Popović ZB, Marwick TH. Normal ranges of left ventricular strain: a meta-analysis. J Am Soc Echocardiogr. 2013;26(2):185-9.

Biering-Sørensen T, Biering-Sørensen SR, Olsen FJ, Sengeløv M, Jørgensen PG, Mogelvang R, Shah AM, Jensen JS. Global longitudinal strain by echocardiography predicts long-term risk of cardiovascular morbidity and mortality in a low-risk general population: The Copenhagen City Heart Study. Circ Cardiovasc Imaging. 2017;10(3): e005521.

Vijayaraghavan G, Sivasankaran S. Global longitudinal strain: A practical step-by-step approach to longitudinal strain imaging. J Indian Acad Echocardiogr Cardiovasc Imaging. 2020;4(1):22–8.

Sane R, Manohar P, Mandole R, Amin G, Ghadigaonkar P, Dongre S, Yanshwantrao P, Patil D, Jadhav R. Impact of Ayurveda based ischemia reversal program (IRP) and polyherbal medication on reduction of resting myocardial ischemia with speckle tracking global longitudinal strain imaging in type 2 diabetes mellitus patients. International Journal of Innovative Research in Medical Science. 2022;7(8): 416–419.

Sane R, Manohar P, Mandole R, Amin G, Ghadigaonkar P, Patil D, Dongre S, Jadhav R, Yanshwantrao P. Impact of Ayurveda‑based Ischemia Reversal Program on reduction of resting myocardial ischemia studied with speckle‑ tracking global longitudinal strain imaging. J Indian Coll Cardiol. 2022;12: 106-10.

Turakhia MP, Schiller NB, Whooley MA. Prognostic significance of increased left ventricular mass index to mortality and sudden death in patients with stable coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2008;102(9): 1131-5.