Evaluation of the Efficacy of the Heart Failure Reversal Therapy (HFRT) in Heart Failure Patients with Reduced Ejection Fraction

Syeda Sumera Imran *

Madhavbaug Clinic Dhantoli, Nagpur, India.

Sadik Khan

Pune and Vidarbha Region, Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India.

Imran Sabir

Madhavbaug Clinic, Bhandara, India.

Rahul Mandole

Department of Research & Development, Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India.

*Author to whom correspondence should be addressed.


Background: Heart failure is a condition where the heart's ability to pump enough blood to support normal metabolic functions is impaired. This causes the heart's resting pressure to rise. Since it has afflicted about 26 million people globally, some authors believe that HF is currently pandemic. Heart Failure Reversal Therapy (HFRT) involves dietary control and herbal panchakarma therapy.

Aim: To study the effect of HFRT on ejection fraction in chronic heart failure patients with reduced ejection fraction.

Results: A total of 27 patients with HF and EF < 40% were enrolled in the study for analysis. There was a significant improvement in VO2peak, from 19.68ml/kg/min at baseline to 32.51 ml/kg/min on day 90. The Mean ± SD on day 1 was19.68±8.84 which improved to 32.51±5.52. The VO2peak was statistically significant (p=0.00). Even more significant improvement was seen in ejection fraction which increased from 35% on Day 1(Mean ± SD = 35.54±12.32) to 53.4% on Day 90(Mean ± SD= 53.46±7.90) and it also showed statistical significance (p=0.00). Also, HR, BMI, abdominal girth, and weight showed similar statistically significant improvements. Improvements in SBP and DBP were not statistically significant.

Conclusion: Along with a reduction in body weight, BMI, and ABG, a significant rise in EF, VO2peak, and 6MWT was seen. For the treatment of HF with low EF, HFRT makes a strong case for consideration as an efficient therapeutic alternative.

Keywords: Heart failure, ejection fraction, heart failure reversal therapy

How to Cite

Sumera Imran, S., Khan, S., Sabir, I., & Mandole, R. (2023). Evaluation of the Efficacy of the Heart Failure Reversal Therapy (HFRT) in Heart Failure Patients with Reduced Ejection Fraction. Asian Journal of Cardiology Research, 6(1), 23–28. Retrieved from https://journalajcr.com/index.php/AJCR/article/view/129


Download data is not yet available.


Tan L, Williams S, Tan D, et al. So many definitions of heart failure: are they all universally valid? A critical appraisal. Expert Rev Cardiovasc Ther. 2010;8:217-28.

Nag T, Ghosh A. Cardiovascular disease risk factors in Asian Indian population: A systematic review. Journal of Cardiovascular Disease Research. 2014; 4(4):222–8.

Prabhakaran D, Jeemon P, Roy A. Cardiovascular Diseases in India. Circulation. 2016;133(16):1605-20.

Huffman MD, Prabhakaran D. Heart failure: Epidemiology and prevention in India. Natl Med J India. 2010;23:283-288.

Metra M, Teerlink JR. Heart failure. Lancet. 2017;390(10106):1981–95.

Yancy C, Jessup M, Bozkurt B, et al. ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013; 62(16):e147-e239.

Rohit Sane, Rahul Mandole “To study the efficacy of Heart Failure Reversal Therapy (HFRT) program in elderly male patients with reduced ejection fraction” International Journal of Medical and Health Research, Volume 4, Issue 7, July 2018, Pages 149-154.

Kemps H, De Vries W, Hoogeveen A, et al. Reproducibility of onset and recovery oxygen uptake kinetics in moderately impaired patients with chronic heart failure. Eur. J Appl. Physiol. 2007; 100(1):45 - 52.

Keteyian S, Brawner C, Savage P, et al. Peak aerobic capacity predicts prognosis in patients with coronary heart disease. Am Heart J. 2008; 156(2):292 -300.

Sane R, Aklujkar A, Patil A, et al. Effect of heart failure reversal treatment as add-on therapy in patients with chronic heart failure: A randomized, open-label study. Indian Heart Journal. 2017; 69(3):299 -304.

Aune D, Sen A, Norat T, et al. Body Mass Index, Abdominal Fatness, and Heart Failure Incidence and Mortality. A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies. Circulation. 2016; 133:639 -649.

Perwitasari D, Urbayatun S. Treatment Adherence and Quality of Life in Diabetes Mellitus Patients in Indonesia. Sage Open. 2016;1-7.